Key Highlights :
1. Glaucoma is a neurodegenerative disease that causes vision loss and blindness due to a damaged optic nerve.
2. The research team found that retinal ganglion cells suffer mitochondrial deficiency with more metabolic burden on each mitochondrion.
3. This leads to mitochondrial damage and degeneration.
4. By enhancing mitochondrial biogenesis, the team was able to protect the optic nerve from being damaged.
Indiana University School of Medicine researchers have identified a new therapeutic target that could lead to more effective treatment of glaucoma. Glaucoma is a neurodegenerative disease that causes vision loss and blindness due to a damaged optic nerve. By restoring mitochondrial homeostasis, the researchers found that retinal ganglion cells are more efficient in degrading bad mitochondria and producing more energy. This could be a possible pathway to new clinical interventions for glaucoma.
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